#103 - 📑 Journal Club 41

Hello Friends 👋

We were fortunate this week to have so many publications available for review on Journal Club. We reviewed the data just published from the BeNeDuctus trial, the EpoRepair trial and many other articles looking at Late Onset Sepsis, transpyloric feeds, antibiotic duration and NEC and more. This week we are also introducing a few new things. First we are releasing Journal Club Shorts, short podcast episodes for the main articles Daphna and I reviewed on the podcast this week. I have also decided to make available to you all my journal club notes, in case these little research summaries could be value to you on your journey to keep up with the literature. Don't forget to claim your CME credit and to secure your seat for the Delphi conference coming in March 2023. Have a good sunday!

Grab your CME Credit here:

Articles reviewed today in chronological order:

Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus | NEJM

Original Article from The New England Journal of Medicine — Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus

New England Journal of MedicineRenew

Transpyloric feeding is associated with improved oxygenation compared with gastric feeding among non-intubated extremely low birth weight infants - PubMed

The transition from gastric to transpyloric tube feeding was temporally associated with acute improvement in oxygenation for non-intubated infants, but not for intubated infants.

PubMedBharath Srivatsa

High-Dose Erythropoietin in Preterm Infants With Intraventricular Hemorrhage

This preliminary report of a randomized clinical trial assess the safety and short-term outcomes of high-dose erythropoietin in preterm infants with intraventricular hemorrhage.

JAMA NetworkFor Authors

Late-Onset Sepsis Among Very Preterm Infants - PubMed

A substantial proportion of very preterm infants continue to suffer late-onset sepsis, particularly those born at the lowest GAs. Infected infants had higher mortality, and survivors had increased risks of technology-dependent chronic morbidities. The persistent burden and diverse microbiology of la…

PubMedDustin D Flannery

Variability in antibiotic duration for necrotizing enterocolitis and outcomes in a large multicenter cohort - Journal of Perinatology

Journal of Perinatology - Variability in antibiotic duration for necrotizing enterocolitis and outcomes in a large multicenter cohort

NatureIrfan Ahmad

Guilt and regret experienced by parents of children born extremely preterm

To explore decisional regret of parents of extremely preterm babies and analyze neonatal,pediatric and parental factors associated with regret.

The Journal of PediatricsSearch for articles by this author

Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy | NEJM

Original Article from The New England Journal of Medicine — Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy

New England Journal of MedicineRenew

The use of milrinone in neonates with persistent pulmonary hypertension of the newborn - a randomised controlled trial pilot study (MINT 1) - Journal of Perinatology

Journal of Perinatology - The use of milrinone in neonates with persistent pulmonary hypertension of the newborn - a randomised controlled trial pilot study (MINT 1)

NatureAfif EL-Khuffash

The Case for Advance Care Planning in the NICU - PubMed

Many NICUs have reached an inflection point where infant deaths following limitation of life-sustaining treatments outnumber those following unsuccessful resuscitations, and many infants who survive continue to require intensive supports. Families of such infants with serious illness may benefit fro…

PubMedMatthew Lin

Ben's Notes: