Hello Friends ๐
Journal club is Back! We have a great series of paper to review this week. We talk about CRP in early onset sepsis, lumbar puncture attempts in late onset sepsis evaluation, indomethacin prophylaxis and so much more. We also announce the winner of our end-of-year giveaway, generously sponsored by Reckitt-Mead Johnson. We hope you enjoy this week's episode. Happy Sunday.
Make sure to grab your CME credits here:
Diagnostic performance and patient outcomes with C-reactive protein use in early-onset sepsis evaluations
To determine performance of C-reactive protein (CRP) in diagnosis of early-onset sepsis(EOS), and to assess patient outcomes with and without routine use of CRP.

Incidence of and Outcomes After Late-Onset Meningitis Among Children Born Extremely Preterm
This cohort study reports the incidence of late-onset meningitis during birth hospitalization of neonates born extremely preterm and the neurodevelopmental outcomes at 18 to 26 monthsโ corrected age.

Effects of prophylactic indomethacin on morbidity and mortality in infants <25 weeksโ gestation: a protocol driven intention to treat analysis - Journal of Perinatology
Journal of Perinatology - Effects of prophylactic indomethacin on morbidity and mortality in infants <25 weeksโ gestation: a protocol driven intention to treat analysis

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants - Jasani, B - 2022 | Cochrane Library

Resuscitation with intact cord versus clamped cord in late preterm and term neonates: A randomized controlled trial
To compare the effect of intact cord versus clamped cord resuscitation on the physiologictransition of neonates receiving positive-pressure ventilation (PPV) at birth.

Effect of breathing support in very preterm infants not breathing during deferred cord clamping: A randomized controlled trial (The ABC study)
To determine if providing respiratory support to very preterm infants who fail tobreathe regularly during deferred cord clamping (DCC) decreased red cell transfusion.

Risk of seizures in neonates with hypoxic-ischemic encephalopathy receiving hypothermia plus erythropoietin or placebo - Pediatric Research
Pediatric Research - Risk of seizures in neonates with hypoxic-ischemic encephalopathy receiving hypothermia plus erythropoietin or placebo

Targeted new screening for congenital cytomegalovirus infection: clinical, audiological and neuroimaging findings
Objective To evaluate clinical, audiological and neuroimaging findings in a cohort of infants diagnosed with congenital cytomegalovirus (cCMV) infection after failure at newborn hearing screening. Methods A prospective observational study in the Netherlands, using the existing newborn hearing screeโฆ

Adverse effects of COVID-19 pandemic on a multicenter randomized controlled trial - Journal of Perinatology
Journal of Perinatology - Adverse effects of COVID-19 pandemic on a multicenter randomized controlled trial

Here are Ben's notes on the articles he presented this week:
Here are Priya's notes as well: