#052 - Journal Club 25

#052 - Journal Club 25


Cochrane review of COX-I for PDA prophylaxis, 50-year preemie follow up, Precedex, and more...

Hello friends 👋

Two journal club weeks back to back! Thankfully we are not short of important articles to review. This week we are reviewing some fascinating article. A study published in the Lancet from an Australian group of researchers who followed preterm infants in their mid fifties to assess for the risk of COPD! Daphna reviewed for us a short report on the effects of dexmedetomidine on cerebral activity via EEG monitoring. This paper may tame our excitement for this new medication.... you tell us. We also reviewed a paper looking at the effects of storing irradiated PRBC versus transfusing freshly irradiated PRBC, some very interesting results there too. Most notably, we reviewed a Cochrane review published a few days ago looking at COX-I for the prophylactic treatment of PDA. We are fortunate enough that the study's first author, Dr. Souvik Mitra, joins us live to breakdown the study design and the main outcomes of the meta-analysis. We reviewed a few more papers, most notably a new POC tool to assess for genetic predisposition to aminoglycoside ototoxicity. Anyway, as we said, it was a packed journal club. We hope you enjoy it and will share your feedback by joining the discussion on twitter.


‌             ‌‌                                      Association between very to moderate preterm births, lung function deficits, and COPD at age 53 years: analysis of a prospective cohort study This is the first study to investigate the effect of prematurity on lung function into middle-age. Data show that very-to-moderate prematurity is associated with obstructive lung function deficits including COPD well into the sixth decade of life and that this effect is compounded by personal smokin…                                                                           The Lancet Respiratory Medicine                                     Search for articles by this author                                                                                  

‌                                      Effects of Freshly Irradiated vs Irradiated and Stored Red Blood Cell Transfusion on Cerebral Oxygenation This randomized clinical trial examines the changes in oxygen delivery capacity after administration of gamma-irradiated red blood cell transfusion in preterm infants with anemia.                                                                           JAMA Network                                     For Authors                                                                                  

‌                                      Dexmedetomidine affects cerebral activity in preterm infants The use of dexmedetomidine (DEX) has been extended in preterm newborns, but the effects on cerebral activity and their relationship with haemodynamic changes has not been studied. We retrospectively studied the effects of DEX administered to 10 preterm newborns, assessing amplitude-integrated EEG (…                                                                           ADC Fetal & Neonatal Edition                                                                                  

‌                                      Prophylactic cyclo‐oxygenase inhibitor drugs for the prevention of morbidity and mortality in preterm infants: a network meta‐analysis - Mitra, S - 2022 | Cochrane Library                                                                            The Cochrane Library Trusted evidence. Informed decisions. Better health.                                     Souvik Mitra                                                                                  

‌                                      Time to positivity of blood cultures in neonatal late-onset bacteraemia Objective To determine the time to positivity (TTP) of blood cultures among infants with late-onset bacteraemia and predictors of TTP >36 hours. Design Retrospective cohort study. Setting 16 birth centres in two healthcare systems. Patients Infants with positive blood cultures obtained >72 hours…                                                                           ADC Fetal & Neonatal Edition                                     1                                                                                  

‌                                      Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care This pragmatic prospective implementation trial uses a rapid genotyping platform for the m.1555A>G variant to assess whether this technology could be implemented to avoid aminoglycoside-induced ototoxicity without disrupting normal clinical practice on neonatal intensive care units.                                                                           JAMA Network                                     For Authors