#045 - Journal Club 22

#045 - Journal Club 22

Hello Friends 👋

This week we have a jam-packed journal club. We reviewed a few papers looking at phyisiologic changes in neonates. How does pCO2 and pO2 affect cerebral blood perfusion? How does PRBC transfusion impact PVR, cardiac function and splanchnic saturation? Daphna reviews a bunch of interesting papers looking at salivary cortisol levels in neonates as measure of nicu induced stress, what are the long term outcomes of babies born during the pandemic. She also reviews a paper from Brown University senior authored by Dr. Betty Vohr on how "high risk" neighborhood can affect long term outcomes of neonates. We also review a paper by our friend Dr. Camilia Martin on breast milk xenobiotics and their effects on the devlopment of BPD and ROP in a cohort of preterm neonates. And we review the newest AAP policy statement on Vitamin K and a clinical report on alternative birth practices that is quite informative. Enjoy!


Impact of Carbon Dioxide on Cerebral Oxygenation and Vital Parameters in Stable Preterm and Term Infants Immediately after Birth
Introduction: Carbon dioxide (pCO2) induces changes in the tone of cerebral vessels. The aim of the present study was to evaluate the impact of pCO2 on cerebral regional tissue oxygen saturation (crSO2), cerebral fractional tissue oxygen extraction (cFTOE), and cerebral tissue oxygen extraction (cTO…
NICU-based stress response and preterm infant neurobehavior: exploring the critical windows for exposure - Pediatric Research
Pediatric Research - NICU-based stress response and preterm infant neurobehavior: exploring the critical windows for exposure
The impact of a PDA on tissue oxygenation and haemodynamics following a blood transfusion in preterm infants - Pediatric Research
Pediatric Research - The impact of a PDA on tissue oxygenation and haemodynamics following a blood transfusion in preterm infants
Association of Birth With vs Without Maternal SARS-CoV-2 Infection Exposure With Neurodevelopment
This cohort study examines neurodevelopmental status at age 6 months of infants born during the peak of the COVID-19 pandemic in New York City, comparing those with vs without in utero exposure to maternal SARS-CoV-2 infection, and the full pandemic cohort with a historical cohort.
Acetaminophen and Xenobiotic Metabolites in Human Milk and the Development of Bronchopulmonary Dysplasia and Retinopathy of Prematurity in a Cohort of Extremely Preterm Infants
This retrospective cohort study sought to identify the association between certainxenobiotic metabolites in maternal breast milk and the diagnoses of bronchopulmonarydysplasia and retinopathy of prematurity in extremely preterm infants. Several acetaminophenmetabolites were associated with a 3- t…
High-Risk Neighborhoods and Neurodevelopmental Outcomes in Infants Born Preterm
To study the association between neighborhood risk and moderate to severe neurodevelopmentalimpairment (NDI) at 22-26 months corrected age in children born at <34 weeks of gestation.We hypothesized that infants born preterm living in high-risk neighborhoods wouldhave a greater risk of NDI and cog…
Vitamin K and the Newborn Infant
Intramuscular administration of vitamin K for prevention of vitamin K deficiency bleeding (VKDB) has been a standard of care since the American Academy of Pediatrics recommended it in 1961. Despite the success of prevention of VKDB with vitamin K administration, the incidence of VKDB appears to be o…
Risks of Infectious Diseases in Newborns Exposed to Alternative Perinatal Practices
The purpose of this report is to educate providers about the risk of infectious diseases associated with emerging alternative peripartum and neonatal practices. This report will provide information pediatricians may use to counsel families before birth and to appropriately evaluate and treat neonate…

This episode of the podcast is proudly sponsored by Chiesi.