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#111-115 - Extubation Readiness in the NICU

Hello Friends 👋

Daphna and I are very happy to bring to you another week of neonatology review content! This time, we are honored to hand the mic to the amazing Dr. Lindsey Knake MD from the University of Iowa. Lindsey takes us on a tour of the evidence surrounding the topic of extubation readiness in the NICU. Lindsey did a phenomenal job and to top it all off, we all had the opportunity to chat with the great Dr. Guilherme Sant'Anna MD, from the University of Montreal, and an expert in the area of extubation readiness in the NICU. As always, please remember to grab your powerpoint presentation of the content we covered this week.

Thank you all.

Link to download the PowerPoint and notes from these episodes 👇

The articles covered on this series of episodes can be found here 👇

Predictors of extubation readiness in preterm infants: a systematic review and meta-analysis.

Shalish W, Latremouille S, Papenburg J, Sant'Anna GM.Arch Dis Child Fetal Neonatal Ed. 2019 Jan;104(1):F89-F97. doi: 10.1136/archdischild-2017-313878. Epub 2018 Mar 8.PMID: 29519808

Decision to extubate extremely preterm infants: art, science or gamble?

Shalish W, Keszler M, Davis PG, Sant'Anna GM.Arch Dis Child Fetal Neonatal Ed. 2022 Jan;107(1):105-112. doi: 10.1136/archdischild-2020-321282. Epub 2021 Feb 24.PMID: 33627331 Review.

Assessment of Extubation Readiness Using Spontaneous Breathing Trials in Extremely Preterm Neonates.

Shalish W, Kanbar L, Kovacs L, Chawla S, Keszler M, Rao S, Latremouille S, Precup D, Brown K, Kearney RE, Sant'Anna GM.JAMA Pediatr. 2020 Feb 1;174(2):178-185. doi: 10.1001/jamapediatrics.2019.4868.PMID: 31860014 Free PMC article.

Age at First Extubation Attempt and Death or Respiratory Morbidities in Extremely Preterm Infants.

Shalish W, Keszler M, Kovacs L, Chawla S, Latremouille S, Beltempo M, Kearney RE, Sant'Anna GM.J Pediatr. 2023 Jan;252:124-130.e3. doi: 10.1016/j.jpeds.2022.08.025. Epub 2022 Aug 24.PMID: 36027982

Predicting extubation outcome in preterm newborns: a comparison of neural networks with clinical expertise and statistical modeling.

Mueller M, Wagner CL, Annibale DJ, Hulsey TC, Knapp RG, Almeida JS.Pediatr Res. 2004 Jul;56(1):11-8. doi: 10.1203/01.PDR.0000129658.55746.3C. Epub 2004 May 5.PMID: 15128922

Machine learning to predict extubation outcome in premature infants.

Mueller M, Wagner CC, Stanislaus R, Almeida JS.Proc Int Jt Conf Neural Netw. 2013 Aug;2013:1-6. doi: 10.1109/IJCNN.2013.6707058.PMID: 25485175 Free PMC article.

Effects of Multiple Ventilation Courses and Duration of Mechanical Ventilation on Respiratory Outcomes in Extremely Low-Birth-Weight Infants.

Jensen EA, DeMauro SB, Kornhauser M, Aghai ZH, Greenspan JS, Dysart KC.JAMA Pediatr. 2015 Nov;169(11):1011-7. doi: 10.1001/jamapediatrics.2015.2401.PMID: 26414549 Free PMC article.

A predictive model for extubation readiness in extremely preterm infants.

Gupta D, Greenberg RG, Sharma A, Natarajan G, Cotten M, Thomas R, Chawla S.J Perinatol. 2019 Dec;39(12):1663-1669. doi: 10.1038/s41372-019-0475-x. Epub 2019 Aug 27.PMID: 31455825

High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure.

Dreyfuss D, Soler P, Basset G, Saumon G.Am Rev Respir Dis. 1988 May;137(5):1159-64. doi: 10.1164/ajrccm/137.5.1159.PMID: 3057957

Predicting extubation outcomes using the Heart Rate Characteristics index in preterm infants: a cohort study.

Chakraborty M, Watkins WJ, Tansey K, King WE, Banerjee S.Eur Respir J. 2020 Oct 1;56(4):1901755. doi: 10.1183/13993003.01755-2019. Print 2020 Oct.PMID: 32444402 Free article. Clinical Trial.

Automated prediction of extubation success in extremely preterm infants: the APEX multicenter study.

Kanbar LJ, Shalish W, Onu CC, Latremouille S, Kovacs L, Keszler M, Chawla S, Brown KA, Precup D, Kearney RE, Sant'Anna GM.Pediatr Res. 2023 Mar;93(4):1041-1049. doi: 10.1038/s41390-022-02210-9. Epub 2022 Jul 29.PMID: 35906315

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