#071-075: Retinopathy of Prematurity

#071-075: Retinopathy of Prematurity

Incubator & Neonatology Review Podcast


Hello  friends 👋

This week we are discussing the topic of retinopathy of prematurity. This is a fascinating pathology that spans the history of neonatology. We start off the week with the history of ROP, or should we say retrolental fibroplasia. This saga takes us to Massachussets in the 1940s to Melbourne, Australia and the United Kingdom. We also reviewed the pathophysiology of ROP and the multiple trials looking at oxygen saturation and ROP. We reviewed some of the most commonly used treatment modalities and some of the controversies surrounding bevacizumab. Finally, on Friday we had the privilege of chatting with Dr. Edward Wood, a vitreoretinal surgeon, expert in management of all diseases of the retina and vitreous in both adults and children. He described to us what the follow up of babies with ROP looks like and what are some of the gaps in knowledge in this areas.

We are linking to many of the articles mentioned on the show this week.

We are also sharing a presentation covering the content discussed on the podcast to help you teach the material.


Link to download the powerpoint: https://docs.google.com/presentation/d/1On3omBNaoJhbCZdpBpdudBoomm9sqZC3/edit?usp=sharing&ouid=102433794540301590359&rtpof=true&sd=true


Ben's notes on the SUPPORT trial and the BEAT ROP trial:

Daphna's notes on BOOST I, BOOST II and STOP ROP:


Fibroblastic Overgrowth of Persistent Tunica Vasculosa Lentis in Infants Born Prematurely: II. Report of Cases—Clinical Aspects
Retrolental Fibroplasia
(Footnotes continued on next page)Introduction Administration of oxygen to premature infants had been implicated as an etiologic agent in the development of retrolental fibroplasia (RLF) prior to late 1952.* But because of the apparently capricious fluctuation in incidence of the disease...

https://www.ajo.com/article/0002-9394(51)90028-1/pdf

https://publications.aap.org/pediatrics/article/105/2/295/62563/Supplemental-Therapeutic-Oxygen-for-Prethreshold

FINAL RESULTS OF THE EARLY TREATMENT FOR RETINOPATHY OF PREMATURITY (ETROP) RANDOMIZED TRIAL
To present the final results of the Early Treatment for Retinopathy of Prematurity Study.Infants with bilateral high-risk prethreshold retinopathy of prematurity (ROP) (n = 317) had one eye randomized to early retinal ablative treatment and the ...

https://publications.aap.org/neoreviews/article-abstract/10/1/e20/88310/Retinopathy-of-PrematurityRecent-Developments?redirectedFrom=fulltext

Target Ranges of Oxygen Saturation in Extremely Preterm Infants | NEJM
Original Article from The New England Journal of Medicine — Target Ranges of Oxygen Saturation in Extremely Preterm Infants
Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity | NEJM
Original Article from The New England Journal of Medicine — Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity

https://publications.aap.org/neoreviews/article-abstract/13/8/e476/91464/Interventions-in-Retinopathy-of-Prematurity?redirectedFrom=fulltext

Oxygen Saturation and Outcomes in Preterm Infants | NEJM
Original Article from The New England Journal of Medicine — Oxygen Saturation and Outcomes in Preterm Infants

https://publications.aap.org/pediatrics/article/142/6/e20183061/37478/Screening-Examination-of-Premature-Infants-for

https://publications.aap.org/pediatrics/article/144/2/e20183537/38499/Neurodevelopmental-Outcomes-of-Preterm-Infants

https://www.aaojournal.org/article/S0161-6420(20)31076-9/fulltext

80 Years of vision: preventing blindness from retinopathy of prematurity - Journal of Perinatology
Journal of Perinatology - 80 Years of vision: preventing blindness from retinopathy of prematurity

https://publications.aap.org/neoreviews/article-abstract/18/2/e84/91774/Identification-and-Treatment-of-Retinopathy-of?redirectedFrom=fulltext