#063 - Journal Club 30

#063 - Journal Club 30

The Incubator Podcast

Hello Friends 👋

A few announcements, this week we released the first episode of Journal Club in spanish. We have a dedicated post on our website but you can subscribe to that show here: https://podcasts.apple.com/us/podcast/the-incubator-español/id1629042188

Also this week, we are happy to finally announce that CME credits for Journal Club episodes are now available. Claiming CME credits is easy, go to the form below answer two content questions (we have to make sure people actually listened to the episode ;) and a few survey questions and you will be emailed a CME certificate automatically. Each Journal Club episode will provide you with 1 CME credit.

There are many interesting articles this week. We review the potential effects of antibiotics in preterm infants at low risk of EOS, the organizational factors that can influence the rates of unplanned extubations in a NICU, methadone vs morphine for neonatal opioid withdrawal syndrome, the effects of transport on mechanical ventilation, and many more articles.

CME form and list of articles are right below 👇, enjoy!


Fill out this form to claim CME credit for listening to this episode:


Early Antibiotic Exposure and Adverse Outcomes in Very Preterm Infants at Low Risk of Early-Onset Sepsis: The EPIPAGE-2 Cohort Study - PubMed
Early empirical antibiotic therapy administrated in very preterm infants at low risk of EOS was associated with a higher risk of severe cerebral lesions and moderate-severe BPD.
Acceleration during neonatal transport and its impact on mechanical ventilation
Objective During interhospital transfer, critically ill neonates frequently require mechanical ventilation and are exposed to physical forces related to movement of the ambulance. In an observational study, we investigated acceleration during emergency transfers and if they result from changes in am…
Active treatment of infants born at 22-25 weeks of gestation in California, 2011-2018 - PubMed
In California, active treatment rates at 23 weeks’ gestation increased between 2011 and 2018; rates at 22 weeks did not. At 22 and 23 weeks, rates increased during the latter part of the week. Several maternal and infant factors were associated with the likelihood of active treatment.
Clinical outcomes of preterm infants while using automated controllers during standard care: comparison of cohorts with different automated titration strategies
Objective To compare short-term clinical outcome after using two different automated oxygen controllers (OxyGenie and CLiO2). Design Propensity score-matched retrospective observational study. Setting Tertiary-level neonatal unit in the Netherlands. Patients Preterm infants (OxyGenie n=121, CLiO2…
Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study - BMC Pediatrics
Background Neonatal Opioid Withdrawal Syndrome (NOWS) is a significant public health issue and while millions of neonates are affected each year, an optimal pharmacologic weaning protocol has yet to be demonstrated. In this study, we compare hospital length of stay (LOS) and length of treatment (LOT…
Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review
Introduction: Multisystem inflammatory syndrome in neonates (MIS-N) related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has increasingly been reported worldwide amid the spread of the SARS-CoV-2 pandemic. Methods: We searched PubMed, EMBASE, and CINAHL and preprint servers (Bio…
Organizational risk factors and clinical impacts of unplanned extubation in the NICU - PubMed
Nursing OTR is associated with increased UPEs in the NICU. Among infants born <29 weeks GA, reintubation after UPE is associated with increased length of MV and odds of BPD.
Breastfeeding and overweight/obesity among children and adolescents: a cross-sectional study - BMC Pediatrics
Background Overweight and obesity are major public health crises among children and adolescents and contribute to a significant economic burden. We aimed to investigate the relationship between breastfeeding duration and overweight and obesity in children and adolescents in Qingdao, China in 2017. M…

Decreasing delivery room CPAP-associated pneumothorax at ≥35-week gestational age
We previously reported an increase in pneumothorax after implementing delivery room (DR) continuous positive airway pressure (CPAP) for labored breathing or persistent cyanosis in ≥35-week gestational age (GA) neonates unexposed to DR-positive ...
Extremely premature infants born at 23–25 weeks gestation are at substantial risk for pulmonary hypertension
Extremely low gestational age newborns (ELGANs) represent an especially vulnerable population. Herein, we aimed to determine incidence and severity of pulmonary hypertension associated with bronchopulmonary dysplasia (BPD-PH) in extremely immature ELGANs ...
Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study - Journal of Perinatology
Journal of Perinatology - Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study
Intrapulmonary Volume Changes during Hiccups versus Spontaneous Breaths in a Preterm Infant - PubMed
Hiccups occur at all ages but are most common during fetal development, and accordingly, they are seen regularly in preterm infants. However, the physiologic correlate of hiccups has never been established. We present the case of a preterm infant who developed a spell of hiccups and compared lung vo…
Left Ventricular Dysfunction Persists in the First Week after Re-Warming following Therapeutic Hypothermia for Hypoxic-Ischaemic Encephalopathy - PubMed
Among infants affected by moderate to severe HIE, LV function appears to be more affected than right ventricular function with LV dysfunction persisting after completion of TH. LVFS was not useful to determine dysfunction in this cohort.
Prediction of weaning readiness off nasal CPAP in preterm infants using point-of-care lung ultrasound - PubMed
This study’s primary aim was to assess whether end-expiratory lung ultrasound severity score (expLUSsc) at Day 3 of life, the second week of life, and before weaning off nasal continuous positive airway pressure​​​​​​ (​nCPAP) can predict the weaning readiness off nCPAP trial in preterm infants. The…
Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia - Journal of Perinatology
Journal of Perinatology - Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia