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#116-120 - Surfactant

Hello Friends 👋

This week on the show Daphna and I discuss surfactants! We cover its history, its composition, function, and the various methods with which surfactants can be administered. We hope you enjoy this series of episodes and thank you once again for your support.


Disclosure: Daphna and I have both served as consultants for Chiesi and The Incubator Podcast is supported by Chiesi. We do not perceive that our association with Chiesi impacted our presentation of this topic on this week's series of episodes. Thank you.

Link to download the PowerPoint and notes from these episodes 👇

The articles covered on this series of episodes can be found here 👇

Surfactant therapy and nasal continuous positive airway pressure for newborns with respiratory distress syndrome. Danish-Swedish Multicenter Study Group.

Verder H, Robertson B, Greisen G, Ebbesen F, Albertsen P, Lundstrøm K, Jacobsen T.N Engl J Med. 1994 Oct 20;331(16):1051-5. doi: 10.1056/NEJM199410203311603.PMID: 8090164 Free article. Clinical Trial.


Surfactant for meconium aspiration syndrome in term and late preterm infants.

El Shahed AI, Dargaville PA, Ohlsson A, Soll R.Cochrane Database Syst Rev. 2014 Dec 14;2014(12):CD002054. doi: 10.1002/14651858.CD002054.pub3.PMID: 25504256 Free PMC article. Review.


Early surfactant in spontaneously breathing with nCPAP in ELBW infants--a single centre four year experience.

Kribs A, Vierzig A, Hünseler C, Eifinger F, Welzing L, Stützer H, Roth B.Acta Paediatr. 2008 Mar;97(3):293-8. doi: 10.1111/j.1651-2227.2007.00617.x.PMID: 18298776


The fascinating story of surfactant.

Halliday HL.J Paediatr Child Health. 2017 Apr;53(4):327-332. doi: 10.1111/jpc.13500. Epub 2017 Mar 8.PMID: 28271629 No abstract available.


Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation.

Härtel C, Herting E, Humberg A, Hanke K, Mehler K, Keller T, Mauer I, Frieauff E, Meyer S, Thome UH, Wieg C, Schmidtke S, Kribs A, Göpel W; German Neonatal Network.JAMA Netw Open. 2022 Aug 1;5(8):e2225810. doi: 10.1001/jamanetworkopen.2022.25810.PMID: 35943742 Free PMC article.


Surfactant Administration Through Laryngeal or Supraglottic Airways.

Guthrie SO, Fort P, Roberts KD.Neoreviews. 2021 Oct;22(10):e673-e688. doi: 10.1542/neo.22-10-e673.PMID: 34599065 Review.


Surface tension as a factor in the resistance of neonatal lungs to aeration.

GRUENWALD P.Am J Obstet Gynecol. 1947 Jun;53(6):996-1007. doi: 10.1016/s0002-9378(16)39775-7.PMID: 20247853 No abstract available.


Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Collaborative European Multicenter Study Group.

[No authors listed]Pediatrics. 1988 Nov;82(5):683-91.PMID: 2903480 Clinical Trial.


Surfactant Nebulization to Prevent Intubation in Preterm Infants: A Systematic Review and Meta-analysis.

Gaertner VD, Thomann J, Bassler D, Rüegger CM.Pediatrics. 2021 Nov;148(5):e2021052504. doi: 10.1542/peds.2021-052504. Epub 2021 Oct 28.PMID: 34711678 Review.


Artificial surfactant therapy in hyaline-membrane disease.

Fujiwara T, Maeta H, Chida S, Morita T, Watabe Y, Abe T.Lancet. 1980 Jan 12;1(8159):55-9. doi: 10.1016/s0140-6736(80)90489-4.PMID: 6101413


Lung expansion in the premature rabbit fetus after tracheal deposition of surfactant.

Enhörning G, Robertson B.Pediatrics. 1972 Jul;50(1):58-66.PMID: 4483194 No abstract available.


Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial.

Dargaville PA, Kamlin COF, Orsini F, Wang X, De Paoli AG, Kanmaz Kutman HG, Cetinkaya M, Kornhauser-Cerar L, Derrick M, Özkan H, Hulzebos CV, Schmölzer GM, Aiyappan A, Lemyre B, Kuo S, Rajadurai VS, O'Shea J, Biniwale M, Ramanathan R, Kushnir A, Bader D, Thomas MR, Chakraborty M, Buksh MJ, Bhatia R, Sullivan CL, Shinwell ES, Dyson A, Barker DP, Kugelman A, Donovan TJ, Tauscher MK, Murthy V, Ali SKM, Yossuck P, Clark HW, Soll RF, Carlin JB, Davis PG; OPTIMIST-A Trial Investigators.JAMA. 2021 Dec 28;326(24):2478-2487. doi: 10.1001/jama.2021.21892.PMID: 34902013 Free PMC article. Clinical Trial.

Aerosolized Calfactant for Newborns With Respiratory Distress: A Randomized Trial.

Cummings JJ, Gerday E, Minton S, Katheria A, Albert G, Flores-Torres J, Famuyide M, Lampland A, Guthrie S, Kuehn D, Weitkamp JH, Fort P, Abu Jawdeh EG, Ryan RM, Martin GC, Swanson JR, Mulrooney N, Eyal F, Gerstmann D, Kumar P, Wilding GE, Egan EA; AERO-02 STUDY INVESTIGATORS.Pediatrics. 2020 Nov;146(5):e20193967. doi: 10.1542/peds.2019-3967. Epub 2020 Oct 15.PMID: 33060258 Clinical Trial.

Implementation of surfactant treatment during continuous positive airway pressure.

Bohlin K, Gudmundsdottir T, Katz-Salamon M, Jonsson B, Blennow M.J Perinatol. 2007 Jul;27(7):422-7. doi: 10.1038/ Epub 2007 May 3.PMID: 17476269

Surfactant for pulmonary haemorrhage in neonates.

Aziz A, Ohlsson A.Cochrane Database Syst Rev. 2020 Feb 3;2(2):CD005254. doi: 10.1002/14651858.CD005254.pub4.PMID: 32012227 Free PMC article.

Surface properties in relation to atelectasis and hyaline membrane disease.

AVERY ME, MEAD J.AMA J Dis Child. 1959 May;97(5, Part 1):517-23. doi: 10.1001/archpedi.1959.02070010519001.PMID: 13649082 No abstract available.

Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome.

Abdel-Latif ME, Davis PG, Wheeler KI, De Paoli AG, Dargaville PA.Cochrane Database Syst Rev. 2021 May 10;5(5):CD011672. doi: 10.1002/14651858.CD011672.pub2.PMID: 33970483 Free PMC article.

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