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#096-100 - Group B Streptococcal Disease

Hello Friends 👋

This week, we are reviewing the evidence surrounding Group B Streptococcal (GBS) disease. We chose this topic because of the recent (2019) publication of the AAP's report on the screening and management of infants with GBS disease. You may be familiar with the CDC guidance published in 2010, but did you know that the 2019 revisions were published not by the CDC but rather by the ACOG and the AAP? The AAP recommendations are quite interesting because they offer clinicians three methods of potentially screening for GBS disease in full term infants. We had the pleasure of chatting with the author of this AAP report, Dr. Karen Puopolo MD PhD, on thursday and she explained how she and her team approached the issue of screening for GBS and why they felt that offering several options for screening infants to clinicians was the most comprehensive way of dealing with this issue. Do not forget to download this week's powerpoint presentation.

Link to download the PowerPoint and notes from these episodes 👇

The articles covered on this series of episodes can be found here 👇

Updated Guidance: Prevention and Management of Perinatal Group B Streptococcus Infection.

Dhudasia MB, Flannery DD, Pfeifer MR, Puopolo KM.Neoreviews. 2021 Mar;22(3):e177-e188. doi: 10.1542/neo.22-3-e177.PMID: 33649090

Management of Infants at Risk for Group B Streptococcal Disease.

Puopolo KM, Lynfield R, Cummings JJ; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES.Pediatrics. 2019 Aug;144(2):e20191881. doi: 10.1542/peds.2019-1881. Epub 2019 Jul 8.PMID: 31285392 Review.

Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies.

Stoll BJ, Puopolo KM, Hansen NI, Sánchez PJ, Bell EF, Carlo WA, Cotten CM, D'Angio CT, Kazzi SNJ, Poindexter BB, Van Meurs KP, Hale EC, Collins MV, Das A, Baker CJ, Wyckoff MH, Yoder BA, Watterberg KL, Walsh MC, Devaskar U, Laptook AR, Sokol GM, Schrag SJ, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.JAMA Pediatr. 2020 Jul 1;174(7):e200593. doi: 10.1001/jamapediatrics.2020.0593. Epub 2020 Jul 6.PMID: 32364598 Free PMC article.

A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis.

Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, Kipnis P, Escobar GJ.JAMA Pediatr. 2017 Apr 1;171(4):365-371. doi: 10.1001/jamapediatrics.2016.4678.PMID: 28241253

Stratification of risk of early-onset sepsis in newborns ≥ 34 weeks' gestation.

Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB, Zupancic J, Lieberman E, Draper D.Pediatrics. 2014 Jan;133(1):30-6. doi: 10.1542/peds.2013-1689. Epub 2013 Dec 23.PMID: 24366992 Free PMC article.

Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors.

Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, Smith M, Escobar GJ.Pediatrics. 2011 Nov;128(5):e1155-63. doi: 10.1542/peds.2010-3464. Epub 2011 Oct 24.PMID: 22025590 Free PMC article.

Development and Implementation of an Early-Onset Sepsis Calculator to Guide Antibiotic Management in Late Preterm and Term Neonates.

Kuzniewicz MW, Walsh EM, Li S, Fischer A, Escobar GJ.Jt Comm J Qual Patient Saf. 2016 May;42(5):232-9. doi: 10.1016/s1553-7250(16)42030-1.PMID: 27066927 No abstract available.

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