#066-070: Caffeine for apnea of prematurity
Hello friends 👋
Have you ever wondered: who had the idea to give caffeine to babies? We certainly did. Caffeine is an ubiquitous medication in the NICU, and yet I can hardly remember anyone teaching me about how the practice of treating apnea of prematurity using caffeine came about.
This week Daphna and I do a deep dive into the history of caffeine and the pathophysiology of apnea of prematurity.
The articles discussed on the show this week are linked below.
We are also attaching the notes Daphna and I took on the CAP trial and
We are also sharing a presentation covering the points discussed on this week's podcast episodes. This presentation aims to make clinical teaching more convenient if you wanted to teach the material covered on the podcast this week. Enjoy!
The articles covered on this series of episodes can be found here 👇
Apnoeic attacks in the newborn treated with aminophylline.
Kuzemko JA, Paala J.Arch Dis Child. 1973 May;48(5):404-6. doi: 10.1136/adc.48.5.404.PMID: 4703073 Free PMC article. No abstract available.
Efficacy of caffeine in treatment of apnea in the low-birth-weight infant.
Aranda JV, Gorman W, Bergsteinsson H, Gunn T.J Pediatr. 1977 Mar;90(3):467-72. doi: 10.1016/s0022-3476(77)80718-x.PMID: 14241
Caffeine therapy for apnea of prematurity.
Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W; Caffeine for Apnea of Prematurity Trial Group.N Engl J Med. 2006 May 18;354(20):2112-21. doi: 10.1056/NEJMoa054065.PMID: 16707748 Free article. Clinical Trial.
Long-term effects of caffeine therapy for apnea of prematurity.
Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W; Caffeine for Apnea of Prematurity Trial Group.N Engl J Med. 2007 Nov 8;357(19):1893-902. doi: 10.1056/NEJMoa073679.PMID: 17989382 Free article. Clinical Trial.
Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity.
Schmidt B, Anderson PJ, Doyle LW, Dewey D, Grunau RE, Asztalos EV, Davis PG, Tin W, Moddemann D, Solimano A, Ohlsson A, Barrington KJ, Roberts RS; Caffeine for Apnea of Prematurity (CAP) Trial Investigators.JAMA. 2012 Jan 18;307(3):275-82. doi: 10.1001/jama.2011.2024.PMID: 22253394 Clinical Trial.
Schmidt B, Roberts RS, Anderson PJ, Asztalos EV, Costantini L, Davis PG, Dewey D, D'Ilario J, Doyle LW, Grunau RE, Moddemann D, Nelson H, Ohlsson A, Solimano A, Tin W; Caffeine for Apnea of Prematurity (CAP) Trial Group.JAMA Pediatr. 2017 Jun 1;171(6):564-572. doi: 10.1001/jamapediatrics.2017.0238.PMID: 28437520 Clinical Trial.
Pathophysiologic Mechanisms Underlying Apnea of Prematurity
Richard J. Martin; Jalal M. Abu-Shaweesh; Terry M. Baird Neoreviews (2002) 3 (4): e59–e65.
Notes on the CAP Trial:
Presentation (check presentation notes for more content per slide):